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1

Sterol 14α-Demethylase as a Potential Target for Antitrypanosomal Therapy: Enzyme Inhibition and Parasite Cell Growth

Galina I. Lepesheva, Robert D. Ott, Tatiana Y. Hargrove, Yuliya Y. Kleshchenko, Inge Schuster, W. David Nes, George C. Hill, Fernando Villalta, Michael R. Waterman

Journal:

Chemistry & Biology

Year:

2007

Language:

english

File:

PDF, 1.14 MB

english, 2007

2

Stability and stabilization of immunoglobulin G Langmuir-Blodgett films

I.V. Turko, G.I. Lepesheva, V.L. Chashchin

Journal:

Thin Solid Films

Year:

1993

Language:

english

File:

PDF, 259 KB

english, 1993

3

Sterol 14α-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms

Galina I. Lepesheva, Michael R. Waterman

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2007

Language:

english

File:

PDF, 1.31 MB

english, 2007

4

Direct antigen detection in Langmuir—Blodgett films of immunoglobulin G modified with coproporphyrin-I

Illarion V. Turko, Galina I. Lepesheva, Vadim L. Chashchin

Journal:

Analytica Chimica Acta

Year:

1992

Language:

english

File:

PDF, 409 KB

english, 1992

5

Structural basis for conservation in the CYP51 family

Galina I. Lepesheva, Michael R. Waterman

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2011

Language:

english

File:

PDF, 1.58 MB

english, 2011

6

A model of optical immunosensor for hemoproteins based on Langmuir–Blodgett films of FITC-labelled immunoglobulin G

G.I Lepesheva, T.N Azeva, V.N Knyukshto, V.L Chashchin, S.A Usanov

Journal:

Sensors and Actuators B: Chemical

Year:

2000

Language:

english

File:

PDF, 191 KB

english, 2000

7

Role of Positively Charged Residues Lys267, Lys270, and Arg411 of Cytochrome P450scc (Cyp11A1) in Interaction with Adrenodoxin

N. V. Strushkevich, T. N. Azeva, G. I. Lepesheva, S. A. Usanov

Journal:

Biochemistry (Moscow)

Year:

2005

Language:

english

File:

PDF, 199 KB

english, 2005

8

CYP51: A Major Drug Target in the Cytochrome P450 Superfamily

Galina I. Lepesheva, Tatyana Y. Hargrove, Yuliya Kleshchenko, W. David Nes, Fernando Villalta, Michael R. Waterman

Journal:

Year:

2008

Language:

english

File:

PDF, 506 KB

english, 2008

9

Role of C-terminal sequence of cytochrome P450scc in folding and functional activity

N. V. Strushkevich, I. N. Harnastai, G. I. Lepesheva, S. A. Usanov

Journal:

Biochemistry (Moscow)

Year:

2006

Language:

english

File:

PDF, 536 KB

english, 2006

10

Site-Directed Mutagenesis of Cytochrome P450scc (CYP11A1). Effect of Lysine Residue Substitution on Its Structural and Functional Properties

G. I. Lepesheva, T. N. Azeva, N. V. Strushkevich, A. A. Gilep, S. A. Usanov

Journal:

Biochemistry (Moscow)

Year:

2000

Language:

english

File:

PDF, 252 KB

english, 2000

11

Site-Directed Mutagenesis of Cytochrome P450scc. II. Effect of Replacement of the Arg425 and Arg426 Residues on the Structural and Functional Properties of the Cytochrome P450scc

T.N. Azeva, A.A. Gilep, G.I. Lepesheva, N.V. Strushkevich, S.A. Usanov

Journal:

Biochemistry (Moscow)

Year:

2001

Language:

english

File:

PDF, 1.30 MB

english, 2001

12

Estriol Bound and Ligand-free Structures of Sterol 14α-Demethylase

Larissa M. Podust, Liudmila V. Yermalitskaya, Galina I. Lepesheva, Vladimir N. Podust, Enrique A. Dalmasso, Michael R. Waterman

Journal:

Year:

2004

Language:

english

File:

PDF, 542 KB

english, 2004

13

A Second FMN Binding Site in Yeast NADPH-Cytochrome P450 Reductase Suggests a Mechanism of Electron Transfer by Diflavin Reductases

David C. Lamb, Youngchang Kim, Liudmila V. Yermalitskaya, Valery N. Yermalitsky, Galina I. Lepesheva, Steven L. Kelly, Michael R. Waterman, Larissa M. Podust

Journal:

Year:

2006

Language:

english

File:

PDF, 902 KB

english, 2006

14

Conformational dynamics and molecular interaction reactions of recombinant cytochrome P450scc (CYP11A1) detected by fluorescence energy transfer

Galina I. Lepesheva, Natalya V. Strushkevich, Sergey A. Usanov

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1999

Language:

english

File:

PDF, 298 KB

english, 1999

15

Conformational dynamics in the F/G segment of CYP51 from Mycobacterium tuberculosis monitored by FRET

Galina I. Lepesheva, Matej Seliskar, Charles G. Knutson, Nina V. Stourman, Damjana Rozman, Michael R. Waterman

Journal:

Archives of Biochemistry and Biophysics

Year:

2007

Language:

english

File:

PDF, 533 KB

english, 2007

16

Sterol 14α-demethylase, an abundant and essential mixed-function oxidase

Michael R. Waterman, Galina I. Lepesheva

Journal:

Biochemical and Biophysical Research Communications

Year:

2005

Language:

english

File:

PDF, 198 KB

english, 2005

17

CYP51—the omnipotent P450

Galina I Lepesheva, Michael R Waterman

Journal:

Molecular and Cellular Endocrinology

Year:

2004

Language:

english

File:

PDF, 248 KB

english, 2004

18

[Advances in Parasitology] Chagas Disease, Part A Volume 75 || Targeting Trypanosoma cruzi Sterol 14α-Demethylase (CYP51)

Lepesheva, Galina I.

Year:

2011

Language:

english

File:

PDF, 1.15 MB

english, 2011

19

Structural complex of sterol 14 -demethylase (CYP51) with 14 -methylenecyclopropyl- 7-24, 25-dihydrolanosterol

Hargrove, T. Y., Wawrzak, Z., Liu, J., Waterman, M. R., Nes, W. D., Lepesheva, G. I.

Journal:

The Journal of Lipid Research

Year:

2012

Language:

english

File:

PDF, 1.33 MB

english, 2012

20

Organocatalytic, Enantioselective Synthesis of VNI: A Robust Therapeutic Development Platform for Chagas, a Neglected Tropical Disease

Dobish, Mark C., Villalta, Fernando, Waterman, Michael R., Lepesheva, Galina I., Johnston, Jeffrey N.

Journal:

Organic Letters

Year:

2012

Language:

english

File:

PDF, 503 KB

english, 2012

21

VNI Cures Acute and Chronic Experimental Chagas Disease

Villalta, F., Dobish, M. C., Nde, P. N., Kleshchenko, Y. Y., Hargrove, T. Y., Johnson, C. A., Waterman, M. R., Johnston, J. N., Lepesheva, G. I.

Journal:

The Journal of Infectious Diseases

Year:

2013

Language:

english

File:

PDF, 337 KB

english, 2013

22

Design or screening of drugs for the treatment of Chagas disease: what shows the most promise?

Lepesheva, Galina I

Journal:

Expert Opinion on Drug Discovery

Year:

2013

Language:

english

File:

PDF, 530 KB

english, 2013

23

Dialkylimidazole inhibitors of Trypanosoma cruzi sterol 14α-demethylase as anti-Chagas disease agents

Suryadevara, Praveen Kumar, Racherla, Kishore Kumar, Olepu, Srinivas, Norcross, Neil R., Tatipaka, Hari Babu, Arif, Jennifer A., Planer, Joseph D., Lepesheva, Galina I., Verlinde, Christophe L.M.J., B

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.70 MB

english, 2013

24

Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14α-Demethylase (CYP51) from Leishmania infantum

Hargrove, Tatiana Y., Wawrzak, Zdzislaw, Liu, Jialin, Nes, W. David, Waterman, Michael R., Lepesheva, Galina I.

Journal:

Journal of Biological Chemistry

Year:

2011

Language:

english

File:

PDF, 2.68 MB

english, 2011

25

Corrections to Rational Modification of a Candidate Cancer Drug for Use against Chagas Disease

Kraus, James M., Verlinde, Christophe L. M. J., Karimi, Mandana, Lepesheva, Galina I., Gelb, Michael H., Buckner, Frederick S.

Journal:

Journal of Medicinal Chemistry

Year:

2009

File:

PDF, 568 KB

2009

26

Probing the Interaction of Bovine Cytochrome P450scc (CYP11A1) with Adrenodoxin: Evaluating Site-Directed Mutations by Molecular Modeling †

Usanov, Sergey A., Graham, Sandra E., Lepesheva, Galina I., Azeva, Tamara N., Strushkevich, Natalya V., Gilep, Andrei A., Estabrook, Ronald W., Peterson, Julian A.

Journal:

Year:

2002

Language:

english

File:

PDF, 526 KB

english, 2002

27

Conservation in the CYP51 Family. Role of the B‘ Helix/BC Loop and Helices F and G in Enzymatic Function †

Lepesheva, Galina I., Virus, Cornelia, Waterman, Michael R.

Journal:

Year:

2003

Language:

english

File:

PDF, 389 KB

english, 2003

28

Corrections to Rational Modification of a Candidate Cancer Drug for Use against Chagas Disease

Kraus, James M., Verlinde, Christophe L. M. J., Karimi, Mandana, Lepesheva, Galina I., Gelb, Michael H., Buckner, Frederick S.

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 540 KB

english, 2009

29

Rational Modification of a Candidate Cancer Drug for Use Against Chagas Disease

Kraus, James M., Verlinde, Christophe L. M. J., Karimi, Mandana, Lepesheva, Galina I., Gelb, Michael H., Buckner, Frederick S.

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 458 KB

english, 2009

30

CYP51 from Trypanosoma brucei Is Obtusifoliol-Specific †

Lepesheva, Galina I., Nes, W. David, Zhou, Wenxu, Hill, George C., Waterman, Michael R.

Journal:

Year:

2004

Language:

english

File:

PDF, 314 KB

english, 2004

31

Complexes of Trypanosoma cruzi Sterol 14 -Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease: STRUCTURAL BASIS FOR PATHOGEN SELECTIVITY

Hargrove, T. Y., Wawrzak, Z., Alexander, P. W., Chaplin, J. H., Keenan, M., Charman, S. A., Perez, C. J., Waterman, M. R., Chatelain, E., Lepesheva, G. I.

Journal:

Journal of Biological Chemistry

Year:

2013

Language:

english

File:

PDF, 3.76 MB

english, 2013

32

Sequence variation in CYP51A from the Y strain of Trypanosoma cruzi alters its sensitivity to inhibition

Cherkesova, Tatiana S., Hargrove, Tatiana Y., Vanrell, M. Cristina, Ges, Igor, Usanov, Sergey A., Romano, Patricia S., Lepesheva, Galina I.

Journal:

Year:

2014

Language:

english

File:

PDF, 2.58 MB

english, 2014

33

Novel 3-Nitrotriazole-Based Amides and Carbinols as Bifunctional Antichagasic Agents

Papadopoulou, Maria V., Bloomer, William D., Lepesheva, Galina I., Rosenzweig, Howard S., Kaiser, Marcel, Aguilera-Venegas, Benjamín, Wilkinson, Shane R., Chatelain, Eric, Ioset, Jean-Robert

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.38 MB

english, 2015

34

Dynamics of CYP51: implications for function and inhibitor design

Yu, Xiaofeng, Cojocaru, Vlad, Mustafa, Ghulam, Salo-Ahen, Outi M. H., Lepesheva, Galina I., Wade, Rebecca C.

Journal:

Journal of Molecular Recognition

Year:

2015

Language:

english

File:

PDF, 2.32 MB

english, 2015

35

Crystal Structures of Trypanosoma brucei Sterol 14 -Demethylase and Implications for Selective Treatment of Human Infections

Lepesheva, G. I., Park, H.-W., Hargrove, T. Y., Vanhollebeke, B., Wawrzak, Z., Harp, J. M., Sundaramoorthy, M., Nes, W. D., Pays, E., Chaudhuri, M., Villalta, F., Waterman, M. R.

Journal:

Journal of Biological Chemistry

Year:

2010

Language:

english

File:

PDF, 2.41 MB

english, 2010

36

Structural Insights into Inhibition of Sterol 14 -Demethylase in the Human Pathogen Trypanosoma cruzi

Lepesheva, G. I., Hargrove, T. Y., Anderson, S., Kleshchenko, Y., Furtak, V., Wawrzak, Z., Villalta, F., Waterman, M. R.

Journal:

Journal of Biological Chemistry

Year:

2010

Language:

english

File:

PDF, 3.33 MB

english, 2010

37

CYP51 from Trypanosoma cruzi: A PHYLA-SPECIFIC RESIDUE IN THE B' HELIX DEFINES SUBSTRATE PREFERENCES OF STEROL 14 -DEMETHYLASE

Lepesheva, G. I., Zaitseva, N. G., Nes, W. D., Zhou, W., Arase, M., Liu, J., Hill, G. C., Waterman, M. R.

Journal:

Journal of Biological Chemistry

Year:

2006

Language:

english

File:

PDF, 640 KB

english, 2006

38

VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis

Lepesheva, G. I., Hargrove, T. Y., Rachakonda, G., Wawrzak, Z., Pomel, S., Cojean, S., Nde, P. N., Nes, W. D., Locuson, C. W., Calcutt, M. W., Waterman, M. R., Daniels, J. S., Loiseau, P. M., Villalta

Journal:

The Journal of Infectious Diseases

Year:

2015

Language:

english

File:

PDF, 1.46 MB

english, 2015

39

The First Virally Encoded Cytochrome P450

Lamb, D. C., Lei, L., Warrilow, A. G. S., Lepesheva, G. I., Mullins, J. G. L., Waterman, M. R., Kelly, S. L.

Journal:

Journal of Virology

Year:

2009

Language:

english

File:

PDF, 975 KB

english, 2009

40

Folding Requirements Are Different between Sterol 14alpha -Demethylase (CYP51) from Mycobacterium tuberculosis and Human or Fungal Orthologs

Lepesheva, G. I.

Journal:

Journal of Biological Chemistry

Year:

2001

Language:

english

File:

PDF, 754 KB

english, 2001

41

Mechanistic Analysis of a Multiple Product Sterol Methyltransferase Implicated in Ergosterol Biosynthesis in Trypanosoma brucei

Zhou, W., Lepesheva, G. I., Waterman, M. R., Nes, W. D.

Journal:

Journal of Biological Chemistry

Year:

2006

Language:

english

File:

PDF, 516 KB

english, 2006

42

Novel sterol metabolic network of Trypanosoma brucei procyclic and bloodstream forms

Nes, Craigen R., Singha, Ujjal K., Liu, Jialin, Ganapathy, Kulothungan, Villalta, Fernando, Waterman, Michael R., Lepesheva, Galina I., Chaudhuri, Minu, Nes, W. David

Journal:

Biochemical Journal

Year:

2012

Language:

english

File:

PDF, 1.31 MB

english, 2012

43

Different therapeutic outcomes of benznidazole and VNI treatment in distinct genders of mouse experimental models of Trypanosoma cruzi infection

F. H. Guedes-da-silva, D. G. J. Batista, C. F. França, M. B. Meuser, M. R. S. Simões, J. S. Araújo, C. G. Ferreira, O. C. Moreira, C. Britto, G. Lepesheva, M. D. N. C. Soeiro

Year:

2015

Language:

english

File:

PDF, 2.23 MB

english, 2015

44

Structure-Functional Characterization of Cytochrome P450 Sterol 14α-Demethylase (CYP51B) from Aspergillus fumigatus and Molecular Basis for the Development of Antifungal Drugs

Hargrove, Tatiana Y., Wawrzak, Zdzislaw, Lamb, David C., Guengerich, F. Peter, Lepesheva, Galina I.

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 7.57 MB

english, 2015

45

Ligand tunnels in T. brucei and human CYP51: Insights for parasite-specific drug design

Yu, Xiaofeng, Nandekar, Prajwal, Mustafa, Ghulam, Cojocaru, Vlad, Lepesheva, Galina I., Wade, Rebecca C.

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2015

Language:

english

File:

PDF, 2.47 MB

english, 2015

46

Sterol 14alpha-Demethylase (CYP51) as a Therapeutic Target for Human Trypanosomiasis and Leishmaniasis

I. Lepesheva, Galina, R. Waterman, Michael

Journal:

Current Topics in Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 628 KB

english, 2011

47

SPIE Proceedings [SPIE Wuhan 91 - Wuhan (Wednesday 9 October 1991)] International Conference on Optical Fibre Sensors in China OFS(C) '91 - Direct fluoroimmunoassay in Langmuir-Blodgett films of immunoglobulin G

Turko, Illarion V., Lepesheva, Galina I., Chashchin, Vadim L., Culshaw, Brian, Liao, Yanbiao

Year:

1991

Language:

english

File:

PDF, 350 KB

english, 1991

48

Human sterol 14α-demethylase (CYP51) as a target for anticancer chemotherapy: Towards structure-aided drug design

Hargrove, Tatiana Y., Friggeri, Laura, Wawrzak, Zdzislaw, Sivakumaran, Suneethi, Yazlovitskaya, Eugenia M., Hiebert, Scott W., Guengerich, Frederick Peter, Waterman, Michael R., Lepesheva, Galina I.

Journal:

The Journal of Lipid Research

Year:

2016

Language:

english

File:

PDF, 1.07 MB

english, 2016

49

Biodiversity of CYP51 in trypanosomes

Lepesheva, G.I., Hargrove, T.Y., Ott, R.D., Nes, W.D., Waterman, M.R.

Journal:

Biochemical Society Transactions

Year:

2006

Language:

english

File:

PDF, 328 KB

english, 2006

50

NIH Public Access

Lepesheva, Galina I, Waterman, Michael R

Year:

2012

Language:

english

File:

PDF, 954 KB

english, 2012